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Study Reveals Kidney Dysfunction Is Associated With Higher Risk of Cancer

In Sweden-based research, where the adults were constantly evaluated, it was discovered that due to the poor functioning of the kidney, the risks of occurrence of certain cancers had been increased; particularly urogenital and skin cancers.

Novel research has disclosed an unpretentious elevated risk of skin and urogenital cancers formation in people suffering from mild to severe chronic kidney problems. The research conclusions, to be published in the Clinical Journal of the American Society of Nephrology (CJASN), do not confirm an underlying connection between kidney dysfunction and cancer, but it might contribute to raising consciousness among patients and healthcare professionals, encourage lifestyle alteration if other risk factors related to cancer are there, and validate more vigilant diagnosis.

The major cause of kidney dysfunction is the retention of metabolic waste, which can negatively impact the several processes taking place in the body. Through some researches, it has been concluded that kidney dysfunction may influence the incidence of anemia, heart disease, bone fractures, and maybe cancer.

To search for some strong connection between kidney dysfunction and cancer, a team of researchers at Karolinska Institute, Sweden, conducted an exhaustive investigation over the risk of cancer connected to the complete range of kidney function. The researchers chose a huge representative population, as participants for the study. The selected 719,033 Swedes had an age of 40 Years and above with no earlier family history related to cancer.

In the period of five years, the selected participants were diagnosed, out of which cancer was detected in 9% of the participants.

Based on the person-year analysis, it was found that the bond between kidney function in individuals and cancer occurrence was U-shaped. The researchers analyzed the estimated glomerular filtration rate (eGFR) of kidneys and compared it with the risk of cancer occurrence, which revealed that the individuals with eGFR of 30-59ml/min were at 8% higher risk of cancer incidence than the individuals with eGFR of 90-104ml/min; and around 24% higher risk was observed for participants with eGFR below 30ml/min. Also, the risk associated with kidney dysfunction increased gradually with time.

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