Researchers at the UNC’s (University of North Carolina) LCCC (Lineberger Comprehensive Cancer Center) found a method to make pancreatic cancer cells dependent on one energy supply and then starve them due to it. This finding has incited clinical studies of a new treatment strategy for one of the fatal cancers. The study was published in the journal Nature Medicine. Scientists from UNC’s LCCC and other collaborating institutes report potential results from early lab studies of a treatment tactic that forces pancreatic cancer to depend on a form of energy production known as autophagy, which is also called “self-eating,” in which cells reprocess their own forms for energy. Their diagnosing studies illustrated the advantage of merging a treatment that pushes the cells to depend more greatly on autophagy with other compounds that could obliquely stop that same energy means once they are dependent on it for fuel.
Based on these results, scientists at the UT’s (University of Texas) M.D. Anderson Cancer Center are intending a clinical test of two drugs to test this approach in patients having pancreatic cancer. The project is backed by an institutional grant from the PanCAN (Pancreatic Cancer Action Network). Similar results from a study by scientists at the HCI (Huntsman Cancer Institute) have been published in Nature Medicine. Channing Der—Professor at the UNC—stated, “Autophagy is a procedure by which cancer cells reprocess materials; rather than just eliminating them, they use them again as a source for nutrients.”
Recently, UNC’s LCCC was in news as its study found a higher risk of breast cancer in women after giving birth. According to a large-scale analysis, younger women who have lately had a child might have a greater risk of breast cancer than other women of the same age who do not have kids. The study was published in the Annals of Internal Medicine and stated that childbirth is defensive against breast cancer. Scientists stated that childbirth does become defensive, but it might take over two decades for benefits to emerge.